IJBST 2017 Volume 10 Issue 2
International Journal of BioSciences and Technology (IJBST) ISSN: 0974-3987
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Formulation and Evaluation of Topical Preparations containing Lutein Ester. Vidisha A. Alwani, Purnima D. Amin. IJBST (2017), 10(2):13-19
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Formulation and Evaluation of Topical Preparations containing Lutein Ester
Authors & Affiliation:
Vidisha A. Alwani, Purnima D. Amin
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P.Marg, Matunga (E), Mumbai-400019, Maharashtra, India.
Lutein a xanthophyll is present in plants as fatty-acid esters, with one or two fatty acids bound to the two hydroxyl-groups. For this reason, de-esterfication of Lutein ester to yield free lutein may yield lutein in any ratio from 1:1 to 1:2 molar ratios with the saponifying fatty acid. Lutein and its esters are apparently employed by animals as an antioxidant and for blue light absorption. As ultraviolet (UV) radiation can cause sunburns, wrinkles, lower immunity against infections, premature aging, and cancer, there is permanent need for protection from UV radiation and prevention from their side effects. Lutein esters such as dipalmitate and myristate derived from lutein, are effective antioxidants that protects the Tcells and tissues from the damaging effects of naturally-produced chemicals known as free radicals. Antioxidants such as vitamin E play the additional role role in fighting against free radical species that are the main cause of numerous negative skin changes and topical application of Vitamin E to the skin has been shown to reduce acute and chronic photo damage. Topically applied vitamin E increases hydration of the stratum corneum and increases its water-binding capacity and Vitamin E is a free radical scavenger and an emollient too. Sea Buckthorn oil (SBT) identifies a group of species in the genus Hippophae and the oil can be extracted from either the seeds or the pulp of the fruit. The SBT oil comprises of linoleic acid and α-linolenic acid are the major fatty acids in seed oil, approximately 65% combined of the monounsaturated fatty acid, palmitoleic acid and the saturated fatty acid, palmitic acid, tocopherols, tocotrienols and plant sterols.SBT oil is widely employed in cosmetics for their rejuvenating, restorative and anti-aging action as well as to promote the recovery of various skin conditions, including burns, ulcers, bad healing wounds, skin damage. The objective of the present study is to design, characterize and evaluate the topical formulations containing Lutein ester, Vitamin E and SBT oil such as Cream, lotion and emulgel. The prepared formulations are characterized for their physio-chemical parameters such as pH, spreadability, particle size, rheological properties and occlusivity. Anti-oxidant activity was studies using the DPPH method. Aqueous silicone cream base containing the above mentioned antioxidants were prepared using simple cold processing technique. The stability studies of the prepared formulations was performed at 30° C/65%RH and 40° C/75%RH conditions. From stability study it was observed that the formulations containing the anti-oxidants possessed higher stability in silicone cream formulation compared to the lotion and emulgel formulation. The results revealed that silicone cream base is a stable and efficient vehicle for delivery of the antioxidants through dermal route.
Keywords: Lutein ester, Seabuck Thorn oil, Vitamin E, silicone cream base, lotion, Emulgel.